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While the revised guidance stated that CMS would compare the per unit rebate amount to the alternative per unit rebate amount, as proposed in 428.204, CMS would compare the total rebate amount calculated in proposed 428.201(a) to the alternative total rebate amount, which CMS believes is consistent with the existing regulations for new formulations at 447.509(a)(4)

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However, in accord with normal or tumor phenotype of the cell line, which makes the A549 more proliferative than the 16HBE, we showed higher values of cell apoptosis in normal epithelial cell line (16HBE) rather than in cancer cell line (A549)